Получение арбидола - вопрос №1438556

1) HO-C6H3C(COOH)C(CH3)N-CH3 + SOCl2 + EtOH = HO-C6H3C(C(O)-O-Et)C(CH3)N-CH3 (A) + SO2↑ + 2HCl;

2) HO-C6H3C(C(O)-O-Et)C(CH3)N-CH3 + Ac2O = AcO-C6H3C(C(O)-O-Et)C(CH3)N-CH3 (B) + AcOH;

3) AcO-C6H3C(C(O)-O-Et)C(CH3)N-CH3 + 2Br2 (+T) = AcO-C6H2(Br)C(C(O)-O-Et)C(CH2Br)N-CH3 (C) + 2HBr;

4) AcO-C6H2(Br)C(C(O)-O-Et)C(CH2Br)N-CH3 + PhSH + KOH = HO-C6H2(Br)C(C(O)-O-Et)C(CH2SPh)N-CH3 (D) + KBr + AcOH;

5) HO-C6H2(Br)C(C(O)-O-Et)C(CH2SPh)N-CH3 + NH(Me)2 + HC(O)H (AcOH) = HO-C6H(CH2N(Me)2)(Br)C(C(O)-O-Et)C(CH2SPh)N-CH3 (E) + H2O;

6) HO-C6H(CH2N(Me)2)(Br)C(C(O)-O-Et)C(CH2SPh)N-CH3 + HCl + H2O = HO-C6H(CH2[NH(Me)2]+Cl-)(Br)C(C(O)-O-Et)C(CH2SPh)N-CH3*H2O.